Ingestion of potato starch containing esterified phosphorus increases alkaline phosphatase activity in the small intestine in rats
| Autor: | Michihiro Fukushima, Sayako Ohmi, Hitoshi Mineo, Nao Morikawa, Takahiro Noda, Kyo Ishida, Hideyuki Chiji, Ayaka Machida, Takumi Kanazawa |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Starch Endocrinology Diabetes and Metabolism Biology Zea mays Maize starch Rats Sprague-Dawley Jejunum chemistry.chemical_compound Endocrinology Intestinal mucosa Intestine Small medicine Animals Ingestion Food science Intestinal Mucosa Potato starch Solanum tuberosum Nutrition and Dietetics Esterification food and beverages Alkaline Phosphatase Small intestine Rats medicine.anatomical_structure Biochemistry chemistry Phosphorus Dietary Alkaline phosphatase Plant Preparations |
| Zdroj: | Nutrition Research. 30:341-347 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2010.05.003 |
| Popis: | Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters and plays an important role in phosphorus (P) metabolism. Several nutrients in food have been reported to affect intestinal ALP activity in animal models. Previous reports indicated that high levels of P or phosphate in diets decreased intestinal ALP activity in rats. Because potato starch contains considerable amounts of esterified P, unlike other starch-derived plants, we hypothesized that the feeding of potato starch would decrease ALP activity in the intestinal tract. Male Sprague-Dawley rats (7 weeks old) were fed 3 different types of diet containing 60% corn starch or 1 of 2 types of potato starch with different esterified P content for 1 or 5 weeks. Body weight and food intake of each rat were measured every day throughout the experimental periods. At the end of the feeding periods, the small intestine was removed to determine ALP activity in the mucosal tissues. Significant differences were observed in ALP activity in the small intestine between the 2 feeding periods, among the 4 segments of the small intestine, and among the 3 diet groups. Significant positive linear correlations between the amount of P derived from the starch and mucosal ALP activity were obtained in the jejunum and jejunoileum in rats after feeding for 5 weeks. We concluded, contrary to our hypotheses, that the ingestion of potato starch adaptively increases ALP activity in the upper part of the small intestine of growing rats in an esterified P content-dependent manner. |
| Databáze: | OpenAIRE |
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