Comparison of the AWGS and optimal stratification-defined handgrip strength thresholds for predicting survival in patients with lung cancer
| Autor: | Suyi Li, Chang Wang, Jiami Yu, Ling Zhang, Jing Guo, Tingting Liang, Zheng Zuo, Jie Liu, Li Deng, Wei Li, Xing Liu, Xu Wang, Xiaojie Wang, Xin Lin, Chunhua Song, Zengqing Guo, Investigation on Nutrition Status, Lijuan Liu, Hanping Shi, Yang Fan, Mei Yang, Xiao Chen, Mengyuan Zhang, Hongxia Xu, Miao Yu, Xiangliang Liu, Kaitao Yuan, Na Li, Jiuwei Cui, Feifei Chong, Shoumei Yang, Liangyu Yin |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer mortality
Male medicine.medical_specialty Sarcopenia Nutrition and Dietetics Lung Neoplasms Hand Strength business.industry Endocrinology Diabetes and Metabolism Mean age medicine.disease Cohort Studies Internal medicine Female patient Medicine Humans In patient Female business Lung cancer Cohort study Proportional Hazards Models |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 90 |
| ISSN: | 1873-1244 |
| Popis: | Handgrip strength (HGS) is related to cancer mortality. The aim of this study was to compare the performance of the Asian Working Group for Sarcopenia 2019 (AWGS)- and optimal stratification (OS)-defined HGS thresholds for predicting the survival of patients with lung cancer (LC).We performed an observational cohort study including 3230 patients with LC admitted to five institutions in China from November 2011 to January 2019. Comprehensive baseline and follow-up information was documented. Sex-specific thresholds for identifying patients with a low HGS were defined based on the AWGS (28 kg in men and18 kg in women) and the OS. The associations of a low HGS with survival were estimated by calculating multivariable-adjusted hazard ratios (HRs), and the relationships were flexibly modeled using restricted cubic splines.The study included 1041 women and 2189 men with a mean age of 60 y and a median follow-up time of 761 d. The OS-calculated HGS thresholds were31.2 kg in men and22.4 kg in women. There were significant associations between a low HGS defined by the AWGS (n = 1392; 43.1%) or the OS (n = 2034; 63%) and various nutritional characteristics. An AWGS-defined low HGS was associated with prolonged hospitalization. The OS-defined low HGS group was associated with a 23% greater death hazard than the normal HGS group (HR, 1.23; 95% confidence interval, 1.08-1.40). An n-shaped non-linear association was observed between the HGS and survival in women (P = 0.003).The OS-defined HGS thresholds show better performance than the AWGS for predicting the survival of patients with LC. Additionally, the HGS had n-shaped associations with the overall mortality among female patients with LC. |
| Databáze: | OpenAIRE |
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