Synthesis of new cinnamoyl-amino acid conjugates and in vitro cytotoxicity and genotoxicity studies
| Autor: | Eray Çalışkan, Dilara Altay Öztürk, Kenan Koran, Suat Tekin, Süleyman Sandal, Sultan Erkan, Ahmet Orhan Görgülü, Ahmet Çetin |
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| Přispěvatelé: | ÇALIŞKAN E., Ozturk D. A. , KORAN K., TEKİN S., SANDAL S., ERKAN S., GÖRGÜLÜ A. O. , ÇETİN A. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Cancer Research Aging Alkoloidler Kimya (çeşitli) Clinical Biochemistry Temel Bilimler (SCI) KİMYA MULTİDİSİPLİNER Genel Biyokimya Genetik ve Moleküler Biyoloji Biochemistry Kimya CHEMISTRY Structural Biology Biyokimya BİYOKİMYA VE MOLEKÜLER BİYOLOJİ Yaşlanma Drug Discovery Amino Acids Ovarian Neoplasms İlaç Keşfi Moleküler Biyoloji Temel Bilimler Life Sciences General Medicine Biyokimya Genetik ve Moleküler Biyoloji (çeşitli) MOLECULAR BIOLOGY & GENETICS Chemistry (miscellaneous) Colonic Neoplasms Natural Sciences (SCI) Physical Sciences Molecular Medicine Female Natural Sciences BIOCHEMISTRY & MOLECULAR BIOLOGY Sitogenetik Life Sciences (LIFE) Antineoplastic Agents Bioengineering Molecular Biology and Genetics Biochemistry Genetics and Molecular Biology (miscellaneous) General Biochemistry Genetics and Molecular Biology Structure-Activity Relationship Cell Line Tumor Yaşam Bilimleri Alcaloides Humans Cytogenetic Molecular Biology Moleküler Biyoloji ve Genetik Yapısal Biyoloji General Chemistry Genel Kimya Klinik Biyokimya Fizik Bilimleri Yaşam Bilimleri (LIFE) CHEMISTRY MULTIDISCIPLINARY Caco-2 Cells Drug Screening Assays Antitumor DNA Damage Kanser Araştırmaları |
| Popis: | Amino acid conjugates are described by the reaction of amino acids with bioactive organic groups such as vitamins, hormones, flavonoids, steroids, and sugars. In this study, 12 new conjugates were synthesized by reaction of cinnamic acid derivatives with various amino acids. Cytotoxic studies against four different human cancer cells (MCF7, PC-3, Caco-2, and A2780) were carried out by MTT assay method at five different concentrations. The structure-activity relationships based on the cell viability rates were evaluated. To compare the anticancer activities of the compounds using computational chemistry methods, they were docked against A2780 human ovarian cancer, Michigan Cancer Foundation-7 (MCF7), human prostate cancer (PC-3) and human colon epidermal adenocarcinoma (Caco-2) cell lines and compared with the standard 5-Fluorouracil. The results indicate that the efficacy of cinnamic acid derivatives increases with the presence of amino acids. Comet assay was conducted to understand whether the cell deaths occur through DNA damage mechanism and the results exhibit that the changes in the specified parameters were statistically significant (p |
| Databáze: | OpenAIRE |
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