Human Dental Pulp Stem Cells Differentiate into Neural Crest-Derived Melanocytes and Have Label-Retaining and Sphere-Forming Abilities
| Autor: | Pierre Formstecher, Angelique Stevens, Yves Bailliez, Cecile Olejnik, Hélène Obriot, Thomas Zuliani, Helene LeRoy, Renata Polakowska, Julie Kerr-Conte |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Biology stomatognathic system Dental pulp stem cells Neurosphere Humans Cells Cultured Dental Pulp Stem cell transplantation for articular cartilage repair Multipotent Stem Cells Mesenchymal stem cell Neural crest Cell Differentiation Cell Biology Hematology Cell biology stomatognathic diseases Neural Crest Multipotent Stem Cell Immunology Melanocytes Female Stem cell Developmental Biology Adult stem cell |
| Zdroj: | Stem Cells and Development. 17:1175-1184 |
| ISSN: | 1557-8534 1547-3287 |
| DOI: | 10.1089/scd.2008.0012 |
| Popis: | Adult tissues contain highly proliferative, clonogenic cells that meet criteria of multipotent stem cells and are potential sources for autologous reparative and reconstructive medicine. We demonstrated that human dental pulp contains self renewing human dental pulp stem cells (hDPSCs) capable of differentiating into mesenchymal-derived odontoblasts, osteoblasts, adipocytes, and chondrocytes and striated muscle, and interestingly, also into non-mesenchymal melanocytes. Furthermore, we showed that hDPSC cultures include cells with the label-retaining and sphere-forming abilities, traits attributed to multipotent stem cells, and provide evidence that these may be multipotent neural crest stem cells. |
| Databáze: | OpenAIRE |
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