Comparative absorption of bismuth in Sprague-Dawley rats following oral administration of preparations containing bismuth sucrose octasulfate, bismuth subsalicylate, and bismuth subcitrate
| Autor: | Niranjan Rao, Paul W. Brown, Kin-Kai Hwang, Phyllis Yerino, Jim Chang |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
inorganic chemicals
Male Sucrose Cmax Pharmaceutical Science chemistry.chemical_element Administration Oral Urine Absorption (skin) digestive system Bismuth subsalicylate Bismuth Rats Sprague-Dawley Pharmacokinetics Oral administration medicine Organometallic Compounds Animals Pharmacology (medical) Tissue Distribution Pharmacology Spectrophotometry Atomic Radiochemistry General Medicine bacterial infections and mycoses equipment and supplies digestive system diseases Salicylates Rats Bismuth Subcitrate chemistry Intestinal Absorption Area Under Curve Antacids medicine.drug |
| Zdroj: | Biopharmaceuticsdrug disposition. 18(1) |
| ISSN: | 0142-2782 |
| Popis: | The absorption of bismuth from De-Nol (bismuth subcitrate, DN), Pepto-Bismol (bismuth subsalicylate, PB) and bismuth sucrose octasulfate (BISOS) was examined in male Sprague-Dawley rats after a single oral dose of each compound (60mg bismuth). Bismuth was analysed in blood, urine, kidney, brain, liver, and lung using graphite furnace atomic absorption spectrophotometry. Bismuth Cmax averaged 18.4 +/- 11.6 ng mL(-1) for BISOS, 292 +/- 130 ng mL(-1) for DN, and 21.5 +/- 9.63 ng mL(-1 ) for PB. Cmax was significantly lower for BISOS compared to DN (p0.05) but not significantly different for BISOS compared to PB (p0.05). Bismuth AUC was 1356 +/- 474 ng h(-1) mL (-1) for BISOS, 2129 +/- 452 ng h(-l) mL(-1) for DN, and 1824 +/- 919 ng h(-1) for PB, which indicated a lower extent of absorption from BISOS compared to DN. Kidney, liver, and lung levels of bismuth were also significantly lower for BISOS compared to DN (p0.05). Bismuth urinary excretion was significantly lower for BISOS (0.04 +/- 0.02%) compared to DN (0.27 +/- 0.15%) but not significantly different compared to PB (0.07 +/- 0.03%). These data suggest that the absorption of bismuth following oral administration of bismuth sucrose octasulfate is significantly lower than that from De-Nol and similar to that from Pepto-Bismo. |
| Databáze: | OpenAIRE |
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