Effects of non-drug treatment on liver cells apoptosis during hepatic ischemia-reperfusion injury
| Autor: | Pei-pei Wang, Xia Huang, Shi-yao Fang, Fen-fang Hong, Shu-Long Yang, Mei-wen Yang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cirrhosis medicine.medical_treatment Apoptosis Pharmacology Liver transplantation 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics business.industry Fatty liver General Medicine medicine.disease Liver Transplantation 030104 developmental biology Liver Reperfusion Injury Signal transduction business Liver cancer Reperfusion injury Perfusion |
| Zdroj: | Life sciences. 275 |
| ISSN: | 1879-0631 |
| Popis: | Hepatic ischemia reperfusion injury (HIRI) is an important cause of liver dysfunction after liver transplantation for the patients suffered from fatty liver, non-alcoholic cirrhosis, or liver cancer. It is closely related to liver cells apoptosis. Therefore, how to maintain the stable state of cell apoptosis is important to protect the liver from HIRI. Drug treatment basically applies some active substances directly or indirectly, reducing HIRI. But their toxic side effects limit the clinical applications. Differently, non-drug treatment means making use of other kinds of measures to reduce the damage, such as non-pharmaceutical preparations, surgical methods, inhalation or perfusion gas, and so on. Non-drug treatments have been shown to balance cell apoptosis and reduce liver damage during HIRI. This review summarized the progresses in the roles of non-drug treatments on liver cells apoptosis during HIRI in recent years, focusing on apoptosis inducing factors, its signal transduction pathway, and downstream molecules, etc., expecting to elucidate non-drug treatments of anti-HIRI more systematically. |
| Databáze: | OpenAIRE |
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