The composition of red cell lipids and the activity of two enzymes of the erythrocyte membrane (ATPase and acetylcholinesterase) in primary refractory anemias
| Autor: | V. Brabec, J. Palek, Č. Michalec, L. Mirčevová, M. Vopatová |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
Erythrocytes ATPase Clinical Biochemistry Biology Biochemistry chemistry.chemical_compound Internal medicine medicine Humans Bone Marrow Diseases Phospholipids Adenosine Triphosphatases chemistry.chemical_classification Hyperplasia Red Cell Cholesterol Phosphatidylethanolamines Cell Membrane Biochemistry (medical) Anemia Erythrocyte Aging General Medicine Lipid Metabolism Acetylcholinesterase Anemia Sideroblastic Sphingomyelins Erythrocyte membrane Enzyme medicine.anatomical_structure Endocrinology chemistry Phosphatidylcholines biology.protein Composition (visual arts) Bone marrow |
| Zdroj: | Clinica Chimica Acta. 23:133-138 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(69)90019-9 |
| Popis: | In a group of patients with primary refractory anemia, the content of total red cell cholesterol, total red cell phospholipids and individual phospholipidic fractions and the activity of two enzymes of the erythrocyte membrane—ATPase and acetyl-cholinesterase—were studied. Patients with primary refractory anemia differ from the control group of healthy individuals by a marked decrease in the activity of red cell acetylcholinesterase. This decrease was significantly higher in patients with primary refractory anemia with aplastic bone marrow than in patients with normal or hyperplastic bone marrow. The mechanism underlying this decrease is discussed. On the other hand, other biochemical examinations, i.e. the examination of red cell lipids and the activity of ATPase of erythrocyte ghosts, did not reveal any deviations from normal values in the studied group of patients. |
| Databáze: | OpenAIRE |
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