EXPERIMENTAL PYELONEPHRITIS IN MICE FOLLOWING ASCENDING INFECTION WITHE. COLI

Autor:	Tsutomu Une, Hidemasa Ogawa, Noriko Tanaka
Rok vydání:	1981
Předmět:	Pathology medicine.medical_specialty Strain (chemistry) General Medicine Biology medicine.disease_cause medicine.disease Serum antibody Pathology and Forensic Medicine Lesion Atrophy medicine Chronic pyelonephritis medicine.symptom Pyonephrosis Escherichia coli Pathological
Zdroj:	Pathology International. 31:179-187
ISSN:	1440-1827 1320-5463
DOI:	10.1111/j.1440-1827.1981.tb01363.x
Popis:	Adhesive and invasive strains of Escherichia coli induced chronic pyelonephritis in mice following the acute phase. The pathological features of the induced chronic pyelonephritis were different between the groups of mice infected with these strains. In piliated adhesive strain (E77156)-infection, the kidneys with viable bacilli showed pyonephrosis with incomplete obstruction or atrophy with coarse scar. Mice with these renal lesions showed high serum antibody levels, but histologically recurrent infection was frequent. On the other hand, in non-piliated invasive strain (633–65)-infection, sterile pyelonephritis developed. This chronic lesion was characterized by the migration of antigen-bearing macrophages and lymphocytes and by a negative serum antibody response. In infections with either strain the predominant lymphocytes in the renal lesions were smooth-surfaced T-lymphocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a542cb97592a516342b205e53192daf1 https://doi.org/10.1111/j.1440-1827.1981.tb01363.x Zobrazit plný text záznamu