Opioid‐induced hypogonadism: Pathophysiology, clinical and therapeutics review

Autor:	Sabah H. El-Ghaiesh, Sharifa Yahya Alzaharani, Thomas Antony
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Infertility medicine.medical_specialty Time Factors Hormone Replacement Therapy Physiology Narcotic Antagonists Sexual Behavior Risk Assessment Drug Administration Schedule Naltrexone 03 medical and health sciences 0302 clinical medicine Risk Factors Physiology (medical) medicine Animals Humans Medical prescription Gonadal Steroid Hormones Gonads Intensive care medicine Pharmacology business.industry Hypogonadism Chronic pain medicine.disease Pathophysiology Analgesics Opioid Sexual Dysfunction Physiological Fertility 030104 developmental biology Sexual dysfunction Opioid 030220 oncology & carcinogenesis Female Low-dose naltrexone medicine.symptom business medicine.drug
Zdroj:	Clinical and Experimental Pharmacology and Physiology. 47:741-750
ISSN:	1440-1681 0305-1870
Popis:	Opioids are pivotal therapeutics in the management of escalated chronic pain (moderate-severe). In the last two decades, the increased prescription rate and the prolonged usage of opioids shed light on opioid-induced endocrinopathy. Opioid-induced hypogonadism (OHG) results upon long-term opioid therapy. Clinically, patients with OHG are presented mainly by sexual dysfunction and infertility. Opioid clinical use in pain therapy is indispensable. However, the resultant sexual endocrinopathy cannot be overlooked and hence hormonal replacement therapy with regular monitoring of the patients represents a potential therapeutic strategy while avoiding opioids in patients with guaranteed long therapeutic exposure and switching to using low-dose naltrexone as alternative represents a possible prophylactic measure to ensure therapeutic compliance and secure a good life quality of patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53f6b9e7c680913b949e7f76b185332 https://doi.org/10.1111/1440-1681.13246 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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