1,1,1-Trichloro-2,2-bis(p-Chlorophenyl)-Ethane (DDT) and Reduced Bone Mineral Density

Autor:	Roger Bronks, Robert U. Newton, Brendan Humphries, Sonya Marshall, Kathy Jong, John R. Beard, Travis Triplett-McBride
Rok vydání:	2000
Předmět:	Insecticides medicine.medical_specialty Bone density Hormone Replacement Therapy Dichlorodiphenyl Dichloroethylene Metabolite medicine.medical_treatment chemistry.chemical_element Calcium DDT chemistry.chemical_compound Absorptiometry Photon Bone Density Internal medicine medicine Humans Environmental Chemistry General Environmental Science Bone mineral organic chemicals Australia Public Health Environmental and Occupational Health Hormone replacement therapy (menopause) Environmental Exposure Environmental exposure Middle Aged Pesticide Calcium Dietary Endocrinology chemistry Toxicity Regression Analysis Female
Zdroj:	Archives of Environmental Health: An International Journal. 55:177-180
ISSN:	0003-9896
DOI:	10.1080/00039890009603403
Popis:	The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated significantly with age (r = -.36, p = .004), as well as with increases in the log of DDE levels in serum (r = -.27, p = .03). The authors also used multiple-regression analysis to examine the influence of other predictor variables on the relationship between log DDE and bone mineral density. The strongest model (p = .002) included log DDE (p = .018), age (p = .002), and years on hormone replacement therapy (p = .10) as predictor variables, and this model afforded prediction of 21% of bone mineral density variation. These results suggest that past community exposures to DDT may be associated with reduced bone mineral density in women.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53b265e40fdbf95c1cccea5745f8d5b https://doi.org/10.1080/00039890009603403 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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