Research of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelets aggregation activity in patients with heart failure and metabolic disturbances

Autor:	A. V. Sitoshevsky, T. Ye. Suslova, Olga A. Koshelskaya, O. Ogurkova
Rok vydání:	2012
Předmět:	medicine.medical_specialty business.industry Insulin medicine.medical_treatment aggregation heart failure secondary messengers medicine.disease Endocrinology Heart failure Internal medicine diabetes mellitus platelets medicine Medicine Molecular Medicine Platelet In patient business Intracellular
Zdroj:	Bûlleten' Sibirskoj Mediciny, Vol 11, Iss 6, Pp 76-81 (2012)
ISSN:	1819-3684 1682-0363
Popis:	Data of the study of cGMP- and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of the platelet aggregation activity in 25 patients with DM2 and heart failure are presented. 15 healthy volunteers were recruited as a control group. To estimate cAMP- and cGMP-dependent intracellular signaling systems in the realization of insulin antiaggregational effect we used 3-isobutyl-1-methyl-xanthine — inhibitor of the phosphodiesterase V and IV, forskolin — stimulator of adenylate cyclase, zaprinast — specific inhibitor of the phosphodiesterase V. Modifiers of the adenylate cyclase/cAMP system — IBMX and forskolin — had the most prominent effect on the reduction of the aggregation of the isolated platelets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53aa98642a96cff0b9f0dbebcd1907d https://doi.org/10.20538/1682-0363-2012-6-76-81 Zobrazit plný text záznamu