Tracheal aspirate cytology and bronchopulmonary dysplasia
| Autor: | Anne Miot, Gladwyn Leiman, Alan D. Rothberg |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Pathology medicine.medical_specialty Histology Hyaline Membrane Disease Birth weight Gestational Age Suction Pathology and Forensic Medicine Cytology Ductus arteriosus mental disorders medicine Birth Weight Humans Hyaline Bronchopulmonary Dysplasia business.industry Infant Newborn Gestational age General Medicine medicine.disease Tracheal aspirate Trachea Low birth weight medicine.anatomical_structure Bronchopulmonary dysplasia Female medicine.symptom business |
| Zdroj: | Diagnostic Cytopathology. 2:212-216 |
| ISSN: | 1097-0339 8755-1039 |
| DOI: | 10.1002/dc.2840020307 |
| Popis: | Sequential tracheal aspirates from 39 neonates with hyaline membrane disease were examined to correlate cytological findings with the development of bronchopulmonary dysplasia (BPD). A total of 224 tracheal aspirates were examined from these infants, 15 of whom developed BPD as diagnosed by conventional clinical and radiological criteria. Hyperplastic and metaplastic epithelial changes were observed in all infants studied. Dysplastic changes occurred in 14 of 15 who developed BPD, and 14 of 24 who had a normal outcome (P less than 0.02). The exfoliation of dysplastic metaplastic bronchial cells was thus 95% specific and 71% sensitive for the subsequent development of BPD. Factors associated with the development of BPD were very low birth weight and gestational age, persistence of a patent ductus arteriosus, high peak inspiratory pressure (cm of H2O/kg), prolonged assisted ventilation, and rapidity of development of class III (dysplastic) changes in tracheal aspirates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text