Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices
| Autor: | Zhanwei Zhong, Peiran Zhang, John D. Mai, Zhenhua Tian, Thomas P. Witelski, Krishnendu Chakrabarty, Tony Jun Huang, Putong Kang, Xingyu Su, Jian-ping Xia, Joseph Rich, Haodong Zhu, Yuyang Gu, Hunter Bachman, Joseph Rufo |
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| Rok vydání: | 2021 |
| Předmět: |
Physics
0303 health sciences Multidisciplinary GeneralLiterature_INTRODUCTORYANDSURVEY Quantitative Biology::Molecular Networks Acoustics SciAdv r-articles 02 engineering and technology 021001 nanoscience & nanotechnology Vortex Physics::Fluid Dynamics 03 medical and health sciences Nonlinear system Acoustic streaming Engineering Cascade Tweezers Sensitivity (control systems) Acoustic radiation Boundary value problem 0210 nano-technology Research Articles Research Article Applied Physics 030304 developmental biology |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abc7885 |
| Popis: | Decomposition and control of acoustic streaming enable contact-free manipulation of bioanalytes and digitalized liquid handling. Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates unpredictable effects due to its nonlinear nature and high sensitivity to the three-dimensional boundary conditions. Here, we demonstrate acoustohydrodynamic tweezers, which generate stable, symmetric pairs of vortices to create hydrodynamic traps for object manipulation. These stable vortices enable predictable control of a flow field, which translates into controlled motion of droplets or particles on the operating surface. We built a programmable droplet-handling platform to demonstrate the basic functions of planar-omnidirectional droplet transport, merging droplets, and in situ mixing via a sequential cascade of biochemical reactions. Our acoustohydrodynamic tweezers enables improved control of acoustic streaming and demonstrates a previously unidentified method for contact-free manipulation of bioanalytes and digitalized liquid handling based on a compact and scalable functional unit. |
| Databáze: | OpenAIRE |
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