Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice
| Autor: | Adriano Mota Loyola, Suely Nonogaki, Roger Chammas, Daniel K. Hsu, Fu-Tong Liu, Thaissa Lopes de Melo, Paulo Rogério de Faria, Sérgio Vitorino Cardoso |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology Ratón Galectin 3 Clinical Biochemistry medicine.disease_cause Oral carcinogenesis Pathology and Forensic Medicine Mice Tongue Premalignant lesions otorhinolaryngologic diseases Galectin-3 Medicine Animals Molecular Biology business.industry Cancer Anatomical pathology medicine.disease Immunohistochemistry Tongue Neoplasms stomatognathic diseases medicine.anatomical_structure Oral squamous cell carcinoma Cytoplasm business Carcinogenesis Precancerous Conditions |
| Zdroj: | Experimental and Molecular Pathology. 90(2):189-193 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/j.yexmp.2010.12.007 |
| Popis: | Background Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. Aims To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral carcinogenesis. Methods Galectin-3-deficient (gal3 −/− ) and wild-type (gal3 +/+ ) mice were challenged with 4-nitroquinoline-1-oxide in drinking water for 16 weeks and killed at different times. Tongues were removed and the number of dysplasias and carcinomas was counted. An immunohistochemical study for galectin-3 was performed only in the tongue from gal3 +/+ mice. Results In both groups, a reduction of dysplasias and an increase of carcinomas from week 16 to week 32 (p > 0.05) were observed. A predominance of high cytoplasmic and nuclear galectin-3 expression was observed in carcinomas (64.7%) and dysplasias (55.5%), respectively (p > 0.05). The perilesional areas always presented a statistical cytoplasmic and nuclear galectin-3 overexpression. Conclusions Absence of galectin-3 did not directly affect the process of carcinogenesis and a cytoplasm shift of galectin-3 seems to be associated with development of tongue carcinomas. |
| Databáze: | OpenAIRE |
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