Evaluation of bioavailability upon oral administration of cinnarizine-.BETA.-cyclodextrin inclusion complex to beagle dogs
| Autor: | Tadakazu Tokumura, Kimio Tatsuishi, Masanori Kayano, Yoshiharu Machida, Yuki Tsushima, Tsuneji Nagai |
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| Rok vydání: | 1985 |
| Předmět: |
Male
chemistry.chemical_classification Cyclodextrins Cinnarizine Cyclodextrin Chemistry beta-Cyclodextrins Biological Availability General Chemistry General Medicine Absorption (skin) Hydrogen-Ion Concentration Pharmacology Beagle Bioavailability Dogs Solubility Oral administration In vivo Drug Discovery medicine Animals medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 33:2962-2967 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | The bioavailability of cinnarizine (CN) upon oral administration of its β-cyclodextrin complex to beagle dogs was investigated in comparison with that of CN alone. The dissolution rate at pH 3.0-6.8 was increased significantly by inclusion complexation, but there was no difference in the bioavailability of CN after oral administration of β-cylodextrin complex and that of CN alone. The absorption of CN was decreased significantly when CN was administered with NaHCO3. However, no decrease was observed in the case of CN-β-cylodextrin inclusion complex. |
| Databáze: | OpenAIRE |
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