Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets
| Autor: | Michael Sejer Hansen, Peter Junker, Merete Lund Hetland, Hanne Merete Lindegaard, Anne Duer, Kim Hørslev-Petersen, Kirsten Junker, Jakob M Møller, Saida Farah Issa, Mikkel Østergaard |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology lcsh:Diseases of the musculoskeletal system Galectin 3 Cartilage/diagnostic imaging Arthritis Galectin 3/blood Gastroenterology Arthritis Rheumatoid 0302 clinical medicine Interquartile range Galectin-3 Prospective Studies Prospective cohort study Hyaluronan Synovitis Area under the curve Undifferentiated arthritis Blood Proteins Middle Aged Rheumatoid arthritis Female Cartilage degradation Research Article Adult medicine.medical_specialty Galectins Arthritis Rheumatoid/blood 03 medical and health sciences Young Adult Collagen II Internal medicine medicine Humans Aged 030203 arthritis & rheumatology Receiver operating characteristic business.industry medicine.disease Rheumatology Cartilage 030104 developmental biology lcsh:RC925-935 business Synovitis/blood Biomarkers Biomarkers/blood Follow-Up Studies |
| Zdroj: | Issa, S F, Duer-Jensen, A, Østergaard, M, Hørslev-Petersen, K, Hetland, M L, Hansen, M S, Junker, K, Lindegaard, H M, Møller, J M & Junker, P 2017, ' Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets ', Arthritis Research & Therapy , vol. 19, 80 . https://doi.org/10.1186/s13075-017-1282-4 Issa, S F, Duer, A, Østergaard, M, Hørslev-Petersen, K, Hetland, M L, Hansen, M S, Junker, K, Lindegaard, H M, Møller, J M & Junker, P 2017, ' Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets ', Arthritis Research and Therapy, vol. 19, 80 . https://doi.org/10.1186/s13075-017-1282-4 Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-10 (2017) Arthritis Research & Therapy |
| DOI: | 10.1186/s13075-017-1282-4 |
| Popis: | Background Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. Methods One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR). At baseline, demographics and laboratory and clinical disease measures, as well as wrist magnetic resonance imaging (MRI) synovitis, erosion, and bone marrow edema scorings, were recorded. Galectin-3, the type IIA collagen N-terminal propeptide (PIIANP), which is a marker of regenerative cartilage formation, and hyaluronan (HYA), which is prevalent in synovial tissue swellings, were measured by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve analysis was carried out to assess the discriminant capacity of galectin-3 against arthritis subsets. Results Galectin-3 was increased in pre-rheumatoid arthritis (RA) (4.6 μg/l, interquartile range (IQR) 3.8–5.5) versus non-RA (4.0 μg/l, IQR 3.1–4.9; p = 0.03) and controls (3.8 μg/l, IQR 3.0–4.8; p = 0.009). PIIANP was equally depressed in either subset (p |
| Databáze: | OpenAIRE |
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