Half-Body Radiotherapy in the Treatment of Canine Lymphoma
| Autor: | V. E. Valli, Alan M. Norris, Angela Baur, AIlen G. Binnington, Peter J. Fitzpatrick, AIlen Mosseri, Walter D. Rider, Elizabeth J. Laing |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Lymphoma medicine.medical_treatment Disease Gastroenterology Dogs Internal medicine medicine Animals Dog Diseases Radiation Pneumonitis Canine Lymphoma General Veterinary business.industry Remission Induction medicine.disease Surgery Radiation therapy Leukemia Bone marrow suppression Evaluation Studies as Topic Radiation sickness Female business Whole-Body Irradiation |
| Zdroj: | Journal of Veterinary Internal Medicine. 3:102-108 |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | In a Phase I-II study, half-body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs, 11 (79%) had a measurable decrease in tumor size. Five dogs achieved a complete or partial remission with a mean duration of 102 and 54 days, respectively. In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy-resistant tumors. Side effects of treatment were divided chronologically into acute (radiation sickness, tumor lysis), subacute (bone marrow suppression), and chronic (radiation pneumonitis, lymphoma-cell leukemia) syndromes. Complications were more severe in tumor-bearing dogs when compared with healthy control animals. Dogs with small tumor burdens and minimal internal disease had fewer complications compared with those with more advanced disease. |
| Databáze: | OpenAIRE |
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