Yolk Sac Diameter in Early Pregnancy in Maternal Diabetes Mellitus
| Autor: | Jackie Ross, Kypros H. Nicolaides, George I. Papaioannou, Nerea Maiz, Argyro Syngelaki |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Maternal diabetes Early pregnancy factor Type 2 diabetes Crown-Rump Length Ultrasonography Prenatal Pregnancy Diabetes mellitus medicine Humans Yolk sac Retrospective Studies Yolk Sac Type 1 diabetes biology Obstetrics business.industry Obstetrics and Gynecology medicine.disease Gestational diabetes Diabetes Gestational Pregnancy Trimester First Cross-Sectional Studies Diabetes Mellitus Type 1 medicine.anatomical_structure Diabetes Mellitus Type 2 Reproductive Medicine Case-Control Studies biology.protein Gestation Female business |
| Zdroj: | Gynecologic and Obstetric Investigation. 73:16-20 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000328690 |
| Popis: | Aims: To investigate the possible association between maternal diabetes mellitus and increased yolk sac diameter (YSD). Methods: We searched the Early Pregnancy Unit database to identify singleton pregnancies with measurements of embryonic crown-rump length (CRL) and YSD at 6–10 weeks of gestation and subsequent delivery of phenotypically normal neonates. We compared the YSD in patients with pre-gestational and gestational diabetes with those who were unaffected by diabetes. Results: A total of 3,686 cases were identified including 43 (1.2%) with type 1 diabetes, 31 (0.8%) with type 2 diabetes and 71 (1.9%) who subsequently developed gestational diabetes. The measured YSD in both the diabetic and non-diabetic groups were expressed as differences from the expected normal mean for CRL (Δ values). There were no significant differences in ΔYSD between the groups. The median (IQR) ΔYSD was 0.01 (–0.33 to 0.37) mm in the unaffected group, 0.01 (–0.35 to 0.51) mm in type 1 diabetes, –0.02 (–3.44 to 0.27) mm in type 2 diabetes and 0.01 (–0.28 to 0.35) mm in gestational diabetes. Conclusion: After exclusion of miscarriages and embryopathies, pre-gestational and gestational diabetes are not associated with altered YSD. |
| Databáze: | OpenAIRE |
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