18F-Fluciclovine Positron Emission Tomography in Prostate Cancer: A Systematic Review and Diagnostic Meta-Analysis
| Autor: | Luca Burroni, Carmelo Caldarella, Fabio Massimo Fringuelli, Giuseppina Biscontini, Andrea Palucci, Francesco Ceci, Cinzia Romagnolo, Chiara Cottignoli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biochemical recurrence
medicine.medical_specialty Clinical Biochemistry Review 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer lymph node staging 0302 clinical medicine medicine Positron emission Stage (cooking) 18F-Fluciclovine PET/CT lcsh:R5-920 detection of relapse medicine.diagnostic_test business.industry Prostate Cancer medicine.disease Systematic review Positron emission tomography 030220 oncology & carcinogenesis Meta-analysis Tomography Radiology business lcsh:Medicine (General) |
| Zdroj: | Diagnostics Diagnostics, Vol 11, Iss 304, p 304 (2021) |
| ISSN: | 2075-4418 |
| Popis: | Background: to explore the diagnostic accuracy of 18F-Fluciclovine positron-emission tomography (PET) in prostate cancer (PCa), considering both primary staging prior to radical therapy, biochemical recurrence, and advanced setting. Methods: A systematic web search through Embase and Medline was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies performed from 2011 to 2020 were evaluated. The terms used were “PET” or “positron emission tomography” or “positron emission tomography/computed tomography” or “PET/CT” or “positron emission tomography-computed tomography” or “PET-CT” and “Fluciclovine” or “FACBC” and “prostatic neoplasms” or “prostate cancer” or “prostate carcinoma”. Only studies reporting about true positive (TP), true negative (TN), false positive (FP) and false negative (FN) findings of 18F-fluciclovine PET were considered eligible. Results: Fifteen out of 283 studies, and 697 patients, were included in the final analysis. The pooled sensitivity for 18F-Fluciclovine PET/CT for diagnosis of primary PCa was 0.83 (95% CI: 0.80–0.86), the specificity of 0.77 (95% CI: 0.74–0.80). The pooled sensitivity for preoperative LN staging was 0.57 (95% CI: 0.39–0.73) and specificity of 0.99 (95% CI: 0.94–1.00). The pooled sensitivity for the overall detection of recurrence in relapsed patients was 0.68 (95% CI: 0.63–0.73), and specificity of 0.68 (95% CI: 0.60–0.75). Conclusion: This meta-analysis showed promising results in term of sensitivity and specificity for 18F-Fluciclovine PET/CT to stage the primary lesion and in the assessment of nodal metastases, and for the detection of PCa locations in the recurrent setting. However, the limited number of studies and the broad heterogeneity in the selected cohorts and in different investigation protocols are limitation affecting the strength of these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|