Antimycobacterial Labdane Diterpenes from Leucas stelligera
| Autor: | Dhiman Sarkar, Vedavati G. Puranik, Roshan R. Kulkarni, Ketaki Dilip Shurpali, Swati P. Joshi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
Stereochemistry Antitubercular Agents Molecular Conformation India Pharmaceutical Science Microbial Sensitivity Tests Crystallography X-Ray Antimycobacterial Chrysoeriol Flavones Analytical Chemistry Labdane Inhibitory Concentration 50 chemistry.chemical_compound Drug Discovery medicine Humans Organic chemistry Nuclear Magnetic Resonance Biomolecular Leucas Pharmacology chemistry.chemical_classification Lamiaceae Molecular Structure biology Chemistry Organic Chemistry Hep G2 Cells Mycobacterium tuberculosis Velutin biology.organism_classification Complementary and alternative medicine Phytochemical Molecular Medicine Diterpenes Drug Screening Assays Antitumor Diterpene |
| Zdroj: | Journal of Natural Products. 76:1836-1841 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np400002p |
| Popis: | Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1-4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1-4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02-9.80 μg/mL. |
| Databáze: | OpenAIRE |
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