Prognostic Value of the mRNA Expression of Members of the Toll-like Receptor Family in Clear Cell Renal Cell Carcinoma
| Autor: | Payam Hacısalihoğlu, Serdar Yanık, Seda Sabah-Özcan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cultural Studies
Toll-like receptor lcsh:Internal medicine lcsh:Specialties of internal medicine Mrna expression lcsh:R Religious studies lcsh:Medicine Biology medicine.disease rcc lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Clear cell renal cell carcinoma tlr lcsh:RC581-951 medicine Cancer research mrna expression lcsh:RC31-1245 Value (mathematics) |
| Zdroj: | Üroonkoloji Bülteni, Vol 18, Iss 4, Pp 149-153 (2019) |
| ISSN: | 2147-2270 2147-2122 |
| Popis: | Objective:The aim of this study was to examine TLRs expression in tumoral and non-tumoral kidney tissue in patients with clear cell renal cell carcinoma (ccRCC) and to evaluate the prognostic significance of TLRs expression profile in ccRCC.Materials and Methods: TLR 1-10 mRNA expressions were measured by real-time polymerase chain reaction (RT-PCR) in formalin-fixed paraffin-embedded (FFPE) 23 ccRCC tumoral tissue samples and 23 non-tumoral kidney tissue samples.Results:A total of 46 individuals were included in the study. None of the patients had rhabdoid or sarcomatoid features. Lymphovascular invasion was observed in only three patients. RT-PCR analyses revealed TLRs mRNA expressions in 23 ccRCC samples and 23 non-tumoral FFPE kidney tissue samples. TLR (TLR1-10) mRNA expression was significantly increased in FFPE ccRCC tissues according to RT-PCR results (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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