Low‐Density Lipoprotein Cholesterol/High‐Density Lipoprotein Cholesterol Ratio and Carotid Intima‐Media Thickness: A Cohort Study in China
Autor: | Ping Zhao, Changyi Wang, Liming Cao, Hongen Chen, Jing Shi, Jianping Ma, Pei Qin, Fulan Hu, Shan Xu, Dongsheng Hu, Li Wang, Yanmei Lou, Xue Li, Xiaolin Peng |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Carotid Intima-Media Thickness Biochemistry Cohort Studies Young Adult 03 medical and health sciences chemistry.chemical_compound High-density lipoprotein Risk Factors Internal medicine Humans Medicine cardiovascular diseases Aged Ultrasonography 030109 nutrition & dietetics business.industry Cholesterol Cholesterol HDL Organic Chemistry Hazard ratio Cholesterol LDL Cell Biology Middle Aged Atherosclerosis Confidence interval 030104 developmental biology Quartile chemistry Intima-media thickness Cohort cardiovascular system Cardiology Female lipids (amino acids peptides and proteins) business Cohort study |
Zdroj: | Lipids. 56:59-68 |
ISSN: | 1558-9307 0024-4201 |
Popis: | Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio may carry additional information and has been suggested as a better predictor for atherosclerosis progression and cardiovascular disease (CVD) than LDL-C and HDL-C alone. Therefore, we aim to explore the association between LDL-C/HDL-C ratio and high carotid intima-media thickness (CIMT) risk in a large Cohort in Beijing, China. This cohort study included 13,612 adults without high CIMT at first entry and who attended the baseline examination and at least one follow-up annual examination between 2009 and 2016. We used multivariable Cox regression to estimate hazard ratios (HR) with their 95% confidence intervals (CI) for the association between LDL-C/HDL-C ratio and risk of high CIMT. During 37,912 person-years of follow-up, 1996 (1268 men and 728 women) developed high CIMT. Compared with the first quartile of LDL-C/HDL-C ratio, the risk of high CIMT was significantly increased for the fourth quartile of LDL-C/HDL-C ratio (HR = 1.51, 95% CI: 1.29-1.78). We observed a significant association between LDL-C/HDL-C ratio and high CIMT risk comparing LDL-C/HDL-C ratio >2.78 with LDL-C/HDL-C ratio ≤2.78 and significant dose-response relationship between LDL-C/HDL-C ratio and risk of high CIMT. The restricted cubic spline showed a significant nonlinear association between LDL-C/HDL-C ratio and the risk of high CIMT (pnon-linearity = 0.009). We identify a significant association between LDL-C/HDL-C ratio and the risk of high CIMT in the Chinese Cohort study. Future studies are needed to evaluate the effectiveness of reducing LDL-C/HDL-C ratio treatment on the development of high CIMT. |
Databáze: | OpenAIRE |
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