dic(9; 20): A new recurrent chromosome abnormality in adult acute lymphoblastic leukemia
| Autor: | Susanne Schnittger, Dinko Berkovic, Christa Fonatsch, Bernhard Wörmann, Harald Rieder, Dieter Hoelzer, Heinrich Bodenstein, Martin Schwonzen, Wolf-Dieter Ludwig |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research Centromere Chromosomes Human Pair 20 Chromosome 9 Chromosomal translocation DNA Satellite Biology Philadelphia chromosome Polymerase Chain Reaction Chromosome aberration Translocation Genetic 03 medical and health sciences Dicentric chromosome 0302 clinical medicine hemic and lymphatic diseases Genetics medicine Humans Philadelphia Chromosome In Situ Hybridization Fluorescence 030304 developmental biology 0303 health sciences Chromosomes Human Pair 11 Karyotype Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Molecular biology Karyotyping 030220 oncology & carcinogenesis Chromosome abnormality Female Chromosome Deletion Chromosome 20 Chromosomes Human Pair 9 |
| Zdroj: | Genes, Chromosomes and Cancer. 13:54-61 |
| ISSN: | 1098-2264 1045-2257 |
| DOI: | 10.1002/gcc.2870130109 |
| Popis: | Loss of chromosome 20 and rearrangement of the short arm of chromosome 9 were identified by banding analysis of three adult patients with acute lymphoblastic leukemia (ALL). The G-banding pattern suggested an identical deletion of 9p, but, also, an unbalanced translocation with chromosome 20 was taken into consideration. Dual-color chromosome painting with probes for chromosomes 9 and 20 revealed the presence of material from chromosome 20 at the short arm of the abnormal chromosome 9 in all three cases. Centromeric alpha-satellite DNA of both chromosome 9 and chromosome 20 was demonstrated by fluorescence in situ hybridization and indicated the presence of a dicentric chromosome. The hybridization of a YAC clone of the short arm of chromosome 20 proved that the dicentric chromosome contained the short arm of chromosome 20, which had been suspected from the G-banding pattern. Thus, the rearrangement was interpreted as dic(9;20)(p11;q11.?1). Because this was the sole chromosome abnormality in two patients, dic(9;20) may be a primary chromosome aberration in ALL. In one case, a 9q+ chromosome derived from a Philadelphia (Ph) translocation was involved in the formation of the dicentric chromosome. Immunophenotyping revealed CD10+ B-cell precursor ALL in all three cases. Whereas the two patients in whom dic(9;20) was the sole cytogenetically detectable change are in continuous complete remission for 10 and 45 months, respectively, the Ph+ patient relapsed with leukemia and died 8 months after diagnosis. |
| Databáze: | OpenAIRE |
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