Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells
| Autor: | Anna Maria Malfitano, Marvin N. Schwalb, Luciano De Petrocellis, Patrizia Gazzerro, Gokce Altay Toruner, Davide Eletto, Maurizio Bifulco, Seema Husain, Pierangelo Orlando, Emilia Vitale, C. Laezza, Alexandra Terskiy |
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| Přispěvatelé: | Malfitano, Am, Toruner, Ga, Gazzerro, Patrizia, Laezza, C, Husain, S, Eletto, D, Orlando, P, DE PETROCELLIS, L, Terskiy, A, Schwalb, M, Vitale, E, Bifulco, Maurizio |
| Rok vydání: | 2006 |
| Předmět: |
CD36 Antigens
CD3 Complex Polyunsaturated Alkamides Immunology Arachidonic Acids Biology Lymphocyte Activation Peripheral blood mononuclear cell Arvanil chemistry.chemical_compound CD28 Antigens Downregulation and upregulation Transcriptional regulation Humans Immunology and Allergy VCAM-1 Oligonucleotide Array Sequence Analysis Regulation of gene expression Microarray analysis techniques Cell growth Anadamide Human peripheral blood mononuclear cells (PBMCs) hemic and immune systems Anandamide Molecular biology Up-Regulation Cell biology chemistry Leukocytes Mononuclear RNA microarray Capsaicin CD36 Endocannabinoids |
| Zdroj: | 16th Symposium on the Cannabinoids of the International Cannabinoid Research Society, Tihany, 2006 info:cnr-pdr/source/autori:A.M. Malfitano, G.A. Toruner, C. Laezza, S. Husain, P. Gazzerro, D. Eletto, P. Orlando, L. De Petrocellis, A. Terskiry, M. Schwalb, E. Vitale, M. Bifulco/congresso_nome:16th Symposium on the Cannabinoids of the International Cannabinoid Research Society,/congresso_luogo:Tihany/congresso_data:2006/anno:2006/pagina_da:/pagina_a:/intervallo_pagine 16th Symposium on the Cannabinoids of the International Cannabinoid Research Society, pp. 169–169, Tihany, Hungary, 2006 info:cnr-pdr/source/autori:A.M. Malfitano, G.A. Toruner, C. Laezza, S. Husain, P. Gazzerro, D. Eletto, P. Orlando, L. De Petrocellis, A. Terskiry, M. Schwalb, E. Vitale, M. Bifulco/congresso_nome:16th Symposium on the Cannabinoids of the International Cannabinoid Research Society/congresso_luogo:Tihany, Hungary/congresso_data:2006/anno:2006/pagina_da:169/pagina_a:169/intervallo_pagine:169–169 Immunology letters 109 (2007): 145–154. doi:10.1016/j.imlet.2007.02.004 info:cnr-pdr/source/autori:Malfitano AM, Toruner GA, Gazzerro P, Laezza C, Husain S, Eletto D, Orlando P, De Petrocellis L, Terskiy A, Schwalb M, Vitale E, Bifulco M./titolo:Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells./doi:10.1016%2Fj.imlet.2007.02.004/rivista:Immunology letters/anno:2007/pagina_da:145/pagina_a:154/intervallo_pagine:145–154/volume:109 Immunology letters 15 (2007): 145–154. doi:10.1016/j.imlet.2007.02.004 info:cnr-pdr/source/autori:Malfitano A M., Toruner G A., Gazzerro P., Laezza C.,Husain S., Eletto D., Orlando P., De Petrocellis L., Terskiy A.,Schwalb M., Vitale E., Bifulco M./titolo:Arvanil and anandamideup-regulate CD36 expression in human peripheral blood mononuclearcells./doi:10.1016%2Fj.imlet.2007.02.004/rivista:Immunology letters/anno:2007/pagina_da:145/pagina_a:154/intervallo_pagine:145–154/volume:15 |
| DOI: | 10.1016/j.imlet.2007.02.004 |
| Popis: | In this study we analysed the regulation of gene expression by arvanil and anandamide in human peripheral blood mononuclear cells (PBMCs) to clarify their immunosuppressive properties. PBMCs were activated, leading to CD36 down regulation, that was normalized by arvanil and anandamide. We used microarray technology to identify a regulatory pattern associated with cell proliferation in the presence of both substances. CD3-CD28 stimulated PBMCs showed a pattern of up-regulated and down-regulated genes after treatment with these substances. We selected and analysed several genes chosen by their function in the regulation of cell proliferation. We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern. |
| Databáze: | OpenAIRE |
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