Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells
| Autor: | Giulio Berti, Giuseppa Piras, Nikolaos Paschalidis, Fulvio D'Acquisto, Silvia Oggero, Fabio Bellia, Claudio D'Addario, Lorenza Rattazzi, Bernardo Dell'Osso, Mauro Perretti, Carmine M. Pariante, Masahiro Ono |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetically modified mouse T-Lymphocytes Transgene Immunology Mice Transgenic Peripheral blood mononuclear cell Autoimmune Diseases Mice 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Immune system Animals Humans Annexin A1 biology Endocrine and Autonomic Systems Phenotype 030104 developmental biology Anxiogenic biology.protein Antibody 030217 neurology & neurosurgery |
| Popis: | Patients suffering from autoimmune diseases are more susceptible to mental disorders yet, the existence of specific cellular and molecular mechanisms behind the co-morbidity of these pathologies is far from being fully elucidated. By generating transgenic mice overexpressing Annexin-A1 exclusively in T cells to study its impact in models of autoimmune diseases, we made the unpredicted observation of an increased level of anxiety. Gene microarray of Annexin-A1 CD4+ T cells identified a novel anxiogenic factor, a small protein of approximately 21kDa encoded by the gene 2610019F03Rik which we named Immuno-moodulin. Neutralizing antibodies against Immuno-moodulin reverted the behavioral phenotype of Annexin-A1 transgenic mice and lowered the basal levels of anxiety in wild type mice; moreover, we also found that patients suffering from obsessive compulsive disorders show high levels of Imood in their peripheral mononuclear cells. We thus identify this protein as a novel peripheral determinant that modulates anxiety behavior. Therapies targeting Immuno-moodulin may lead to a new type of treatment for mental disorders through regulation of the functions of the immune system, rather than directly acting on the nervous system. |
| Databáze: | OpenAIRE |
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