Simultaneous integrated boost by Intensity Modulated Radiotherapy (SIB-IMRT) in patients undergoing breast conserving surgery – A clinical and dosimetric perspective

Autor: Krati Mehrotra, Munish Gairola, Ajay Kumar Dewan, R. Singh, Rahul Lal Chaudhary, Raman Narang, Swarupa Mitra, Abirama V. Sundari, A.K. Pahuja, P. Pathak, Kundan Singh Chufal, T. Suresh, Abhinav Dewan, S. K. Sharma, Maninder Mishra, Sravya Bommera
Rok vydání: 2018
Předmět:
Adult
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
India
Breast Neoplasms
Mastectomy
Segmental
Logistic regression
lcsh:RC254-282
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
0302 clinical medicine
Breast cancer
Materials Chemistry
Breast-conserving surgery
medicine
Humans
Breast
Prospective Studies
Radiation Injuries
Prospective cohort study
Aged
Neoplasm Staging
Univariate analysis
business.industry
Cosmesis
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Treatment Outcome
030220 oncology & carcinogenesis
Axilla
Inclusion and exclusion criteria
Female
Radiotherapy
Adjuvant
Dose Fractionation
Radiation
Lymph Nodes
Radiotherapy
Intensity-Modulated
Radiology
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: Journal of the Egyptian National Cancer Institute, Vol 30, Iss 4, Pp 165-171 (2018)
ISSN: 1110-0362
DOI: 10.1016/j.jnci.2018.10.001
Popis: Aim: To study feasibility of simultaneous integrated boost by intensity modulated radiotherapy (SIB-IMRT) in patients undergoing breast conserving surgery and its impact on cosmesis and dosimetry. Patients and methods: Between January 2014 and June 2017, all breast cancer patients fulfilling inclusion and exclusion criteria were enrolled in a prospective study conducted at a tertiary cancer centre in North India. All patients received adjuvant radiotherapy by simultaneous integrated boost technique following breast conserving surgery. Clinical information including patient and pathological characteristics, observed acute and chronic toxicities along with cosmesis using Harvard score were recorded and analysed. Univariate analysis and multivariate logistic regression analysis were performed for those variables which were found to be significant (p
Databáze: OpenAIRE
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