Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets
| Autor: | Israel Olapeju Bolanle, Ritchie Williamson, Timothy M. Palmer, Kirsten Riches-Suman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Glycosylation Vascular homeostasis Acylation Cellular functions Hyaluronoglucosaminidase Disease Bioinformatics N-Acetylglucosaminyltransferases Acetylglucosamine O glcnacylation Pathogenesis 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Antigens Neoplasm Acetylglucosaminidase Medicine Transferase Animals Humans Enzyme Inhibitors Histone Acetyltransferases Pharmacology Mechanism (biology) business.industry Cardiovascular Agents Limiting beta-N-Acetylhexosaminidases 030104 developmental biology Cardiovascular Diseases 030220 oncology & carcinogenesis business Protein Processing Post-Translational |
| Zdroj: | Pharmacological research. 165 |
| ISSN: | 1096-1186 |
| Popis: | Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of CVDs remains incomplete. One mechanism that has recently emerged is protein O-GlcNAcylation. This is a dynamic, site-specific reversible post-translational modification of serine and threonine residues on target proteins and is controlled by two enzymes: O-linked β-N-acetylglucosamine transferase (OGT) and O-linked β-N-acetylglucosaminidase (OGA). Protein O-GlcNAcylation alters the cellular functions of these target proteins which play vital roles in pathways that modulate vascular homeostasis and cardiac function. Through this review, we aim to give insights on the role of protein O-GlcNAcylation in cardiovascular diseases and identify potential therapeutic targets in this pathway for development of more effective medicines to improve patient outcomes. |
| Databáze: | OpenAIRE |
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