In vivo reprogramming for heart disease
| Autor: | Kenneth R. Chien, B. Alexander Yi, Huansheng Xu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Heart disease
Somatic cell Cellular differentiation Biology Regenerative Medicine Regenerative medicine medicine Humans Regeneration Cell Lineage Myocytes Cardiac Molecular Biology MyoD Protein Heart Failure Regeneration (biology) Transdifferentiation Cell Differentiation Heart Cell Biology Fibroblasts Cellular Reprogramming medicine.disease Research Highlight Cell biology Cell Transdifferentiation Immunology Reprogramming |
| Zdroj: | Cell Research. 22:1521-1523 |
| ISSN: | 1748-7838 1001-0602 |
| DOI: | 10.1038/cr.2012.101 |
| Popis: | The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative approach for the development of cardiac therapeutics. |
| Databáze: | OpenAIRE |
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