Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus
| Autor: | Bálint Lasztóczi, Thomas Klausberger, Tim J. Viney, Linda Katona, Peter Somogyi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Interneuron
Action Potentials Hippocampus Review Article interneuron Local field potential Biology Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Part IV: Oscillatory networks GABA 03 medical and health sciences 0302 clinical medicine synapse Biological Clocks Neural Pathways medicine Animals Premovement neuronal activity CA1 Region Hippocampal gamma-Aminobutyric Acid 030304 developmental biology 0303 health sciences Pyramidal Cells musculoskeletal neural and ocular physiology food and beverages oscillation CA3 Region Hippocampal Axon initial segment inhibition Axons Rats Parvalbumins medicine.anatomical_structure nervous system GABAergic Pyramidal cell General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Philosophical Transactions of the Royal Society B: Biological Sciences |
| ISSN: | 0962-8436 |
| DOI: | 10.1098/rstb.2012.0518 |
| Popis: | The behaviour-contingent rhythmic synchronization of neuronal activity is reported by local field potential oscillations in the theta, gamma and sharp wave-related ripple (SWR) frequency ranges. In the hippocampus, pyramidal cell assemblies representing temporal sequences are coordinated by GABAergic interneurons selectively innervating specific postsynaptic domains, and discharging phase locked to network oscillations. We compare the cellular network dynamics in the CA1 and CA3 areas recorded with or without anaesthesia. All parts of pyramidal cells, except the axon initial segment, receive GABA from multiple interneuron types, each with distinct firing dynamics. The axon initial segment is exclusively innervated by axo-axonic cells, preferentially firing after the peak of the pyramidal layer theta cycle, when pyramidal cells are least active. Axo-axonic cells are inhibited during SWRs, when many pyramidal cells fire synchronously. This dual inverse correlation demonstrates the key inhibitory role of axo-axonic cells. Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs, together with dendrite-innervating bistratified cells, phasing pyramidal cell discharge. Subcellular domain-specific GABAergic innervation probably developed for the coordination of multiple glutamatergic inputs on different parts of pyramidal cells through the temporally distinct activity of GABAergic interneurons, which differentially change their firing during different network states. |
| Databáze: | OpenAIRE |
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