Effects of co-exposure to CS2 and noise on hearing and balance in rats: continuous versus intermittent CS2 exposures
| Autor: | Elodie Bonfanti, Maria Carreres-Pons, Benoît Pouyatos, Pierre Campo, Hervé Nunge, Jordi Llorens, Frédéric Cosnier, Thomas Venet, Lise Merlen, Aurélie Thomas, Monique Chalansonnet, Stéphane Boucard |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Vestibule
medicine.medical_specialty Ratolins (Animals de laboratori) Carbon disulfide Soroll Audiology Sulfides Toxicology lcsh:RC963-969 03 medical and health sciences Sulfurs 0302 clinical medicine Low-frequency noise medicine otorhinolaryngologic diseases Inner ear Co-exposure Side effects Cochlea Efectes secundaris 030304 developmental biology Balance (ability) Vestibular system 0303 health sciences business.industry Research Public Health Environmental and Occupational Health Noise medicine.anatomical_structure Mice (Laboratory animals) lcsh:Industrial medicine. Industrial hygiene Middle ear Reflex Rat sense organs business Safety Research 030217 neurology & neurosurgery |
| Zdroj: | Journal of Occupational Medicine and Toxicology (London, England) Dipòsit Digital de la UB Universidad de Barcelona Journal of Occupational Medicine and Toxicology, Vol 15, Iss 1, Pp 1-11 (2020) |
| ISSN: | 1745-6673 |
| Popis: | Background Carbon disulfide (CS2) exacerbates the effect of noise on hearing, and disrupts the vestibular system. The goal of this study was to determine whether these effects are also observed with intermittent CS2 exposure. Methods Rats were exposed for 4 weeks (5 days/week, 6 h/day) to a band noise at 106 dB SPL either alone or combined with continuous (63 ppm or 250 ppm) or intermittent (15 min/h or 2 × 15 min/h at 250 ppm) CS2. Hearing function was assessed by measuring distortion product otoacoustic emissions (DPOAEs); balance was monitored based on the vestibulo-ocular reflex (VOR). Functional measurements were performed before, at the end of exposure and 4 weeks later. Histological analyses of the inner ear were also performed following exposure and after the 4-week recovery period. Results The results obtained here confirmed that CS2 exposure exerts two differential temporary effects on hearing: (1) it attenuates the noise-induced DPOAE decrease below 6 kHz probably through action on the middle ear reflex when exposure lasts 15 min per hour, and (2) continuous exposure to 250 ppm for 6 h extends the frequency range affected by noise up to 9.6 kHz (instead of 6 kHz with noise alone). With regard to balance, the VOR was reversibly disrupted at the two highest doses of CS2 (2 × 15 min/h and continuous 250 ppm). No morphological alterations to the inner ear were observed. Conclusion These results reveal that short periods of CS2 exposure can alter the sensitivity of the cochlea to noise at a dose equivalent to only 10 times the short-term occupational limit value, and intermittent exposure to CS2 (2 × 15 min/h) can alter the function of the vestibular system. |
| Databáze: | OpenAIRE |
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