Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
| Autor: | Hironori Kusano, Nobuhiko Higashi, Yui Hongo, Akihiko Nakashima, Seiya Kato, Shusuke Morizono, Kaname Miyashita |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Hepatitis B virus medicine.medical_specialty Lymphoma occult hepatitis C virus infection R-CHOP therapy Hepatitis C virus medicine.medical_treatment Case Report Hepacivirus 030204 cardiovascular system & hematology chemotherapy medicine.disease_cause Gastroenterology Virus 03 medical and health sciences 0302 clinical medicine Internal medicine Ascites Internal Medicine medicine Humans Aged Chemotherapy Hepatitis B Surface Antigens business.industry hepatitis C virus reactivation Cancer General Medicine Hepatitis C medicine.disease Occult digestive system diseases Virus Activation malignant lymphoma 030211 gastroenterology & hepatology medicine.symptom Rituximab business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.4768-20 |
| Popis: | A 79-year-old man with lymphoma who tested negative for anti-hepatitis C virus (HCV) antibody received rituximab-containing chemotherapy. Liver dysfunction of unknown cause had persisted since the second cycle of chemotherapy. Ten months after treatment, he rapidly developed massive ascites and atrophy of the liver, and we detected HCV RNA in his serum using real time polymerase chain reaction. Furthermore, medical interviews showed that the patient had no episodes for acute HCV infection, but he did have a history of unspecified liver dysfunction. These findings support the possibility of the reactivation of seronegative occult HCV infection due to chemotherapy in a cancer patient. |
| Databáze: | OpenAIRE |
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