The role of colonic metabolism in lactose intolerance
| Autor: | Gjalt W. Welling, Robert-Jan M. Brummer, Koen Venema, Tao He, Marion G. Priebe, Roelf Vonk |
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| Přispěvatelé: | TNO Kwaliteit van Leven, Interne Geneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Biomedical Research
Clinical Biochemistry Lactose Review GUT MICROBIOME Biochemistry Gastroenterology chemistry.chemical_compound Lactose Intolerance ANTIBIOTIC-ASSOCIATED DIARRHEA Medicine Flatulence Bifidobacterium Priority journal biology Loose feces Antibiotic agent Lactic acid General Medicine Lactase deficiency Diarrhea CHAIN FATTY-ACIDS Lactates Antibiotic-associated diarrhea medicine.symptom Drug mechanism Human medicine.medical_specialty Colon Probiotic agent Diet supplementation Colon flora Synbiotic agent MECHANISMS Succinic acid Internal medicine Humans Irritable colon Nutrition HUMAN INTESTINE Lactose intolerance Colonic microbiota Prebiotic agent business.industry SUGAR MALABSORPTION Metabolism biology.organism_classification medicine.disease Nonhuman PROBIOTICS digestive system diseases FUNCTIONAL BOWEL-DISEASE Endocrinology chemistry Fermentation OSMOTIC DIARRHEA business |
| Zdroj: | European Journal of Clinical Investigation, 8, 38, 541-547 European Journal of Clinical Investigation, 38(8), 541-7. Wiley |
| ISSN: | 0014-2972 |
| Popis: | Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fermentation metabolites and how these processes would play a role in the pathophysiology of lactose intolerance. We suggest that the balance between the removal and production rate of osmotic-active components (lactose, and intermediate metabolites, e.g. lactate, succinate, etc.) in the colon is a key factor in the development of symptoms. The involvement of the colon may provide the basis for designing new targeted strategies for dietary and clinical management of lactose intolerance. © 2008 The Authors. Chemicals / CAS: lactic acid, 113-21-3, 50-21-5; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; succinic acid, 110-15-6; Lactates; Lactose, 63-42-3 |
| Databáze: | OpenAIRE |
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