The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes
| Autor: | Hyo-Sung Ro, Daniel A. K. Roncari |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Base Sequence
Tumor Suppressor Proteins Fatty Acids Molecular Sequence Data Nuclear Proteins Cell Biology Fatty Acid-Binding Proteins Transfection Neoplasm Proteins DNA-Binding Proteins Enhancer Elements Genetic Adipose Tissue Gene Expression Regulation Genes CCAAT-Enhancer-Binding Proteins Humans Carrier Proteins Fatty Acid-Binding Protein 7 Molecular Biology Cells Cultured Research Article |
| Zdroj: | Molecular and cellular biology. 11(4) |
| ISSN: | 0270-7306 |
| Popis: | Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3' AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|