Effect of retinyl acetate on transglutaminase 2 activity in carcinogen treated rat liver

Autor:	Dilek Burukoglu, Irfan Degirmenci, Özlem Aydın, Hilmi Ozden, Neslihan Tekin, Mc Ustuner, Fahrettin Akyüz
Přispěvatelé:	[Aydin, O. -- Akyuz, F.] Eskisehir Osmangazi Univ, Dept Med Biochem, Fac Med, Eskisehir, Turkey -- [Tekin, N.] Aksaray Univ, Fac Sci & Letters, Dept Biotechnol & Mol Biol, TR-68100 Aksaray, Turkey -- [Ustuner, M. C. -- Degirmenci, I.] Eskisehir Osmangazi Univ, Fac Med, Dept Med Biol, Eskisehir, Turkey -- [Burukoglu, D.] Eskisehir Osmangazi Univ, Fac Med, Histol & Embryol, Eskisehir, Turkey -- [Ozden, H.] Eskisehir Osmangazi Univ, Fac Med, Anat, Eskisehir, Turkey, Sabire Yazıcı Fen Edebiyat Fakültesi
Rok vydání:	2016
Předmět:	Male 0301 basic medicine Retinyl Esters medicine.medical_specialty Polychlorinated Dibenzodioxins Histology Tissue transglutaminase Retinyl acetate Kidney liver Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine GTP-Binding Proteins Internal medicine medicine Animals Protein Glutamine gamma Glutamyltransferase 2 rat Vitamin A Carcinogen Transglutaminases retinyl acetate biology Organ Size General Medicine transglutaminase 2 medicine.disease Enzyme assay carcinogen Medical Laboratory Technology 030104 developmental biology Endocrinology chemistry Apoptosis 030220 oncology & carcinogenesis Carcinogens biology.protein Diterpenes Liver cancer Corn oil Immunostaining
Zdroj:	Biotechnic & Histochemistry. 91:342-351
ISSN:	1473-7760 1052-0295 0003-7966
Popis:	WOS: 000379664700004 PubMed: 27089473 Transglutaminase 2 (TG2) has been implicated in wound healing, cellular differentiation, apoptosis and cell survival. TG2 activity increases following acute and chronic liver injury; however, the role of TG2 in tumors, is controversial. TG2 is a retinoid-inducible enzyme. We investigated the effects of retinyl acetate (RA) on the activity and levels of TG2 during the initiation and promotion stages of liver cancer. p-Dimethylaminoazobenzene (p-DAB) was used as initiator and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was used as promoter in our model of carcinogenesis. Rats were divided into four groups of 24: control, corn oil control, p-DAB + TCDD, and p-DAB + TCDD + RA. Six rats from each group were sacrificed at days 30, 60, 90 and 120. TG2 activity decreased in the p-DAB + TCDD treated group, but TG2 immunostaining scores did not change by days 90 and 120. Neither TG2 enzyme activity nor the immunostaining score of TG2 protein changed in the tissues of the p-DAB + TCDD + RA group by days 90 and 120. TG2 activity was not be ameliorated by RA during the initiation or promotion stages of carcinogen induced liver cancer. Research Foundation of Eskisehir Osmangazi University, Turkey [200811016] Our study was supported by Grant no. 200811016 from the Research Foundation of Eskisehir Osmangazi University, Turkey.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51cabca16b3b05cd8ce3b429dd25e5a https://doi.org/10.3109/10520295.2016.1170879 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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