MRI-visible nanoparticles from hydrophobic gadolinium poly(ε-caprolactone) conjugates
| Autor: | Xavier Garric, Benjamin Nottelet, Barbara Porsio, Sarah El Habnouni, Laurent Lemaire, Florence Franconi, Jean Coudane, Vincent Darcos |
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| Přispěvatelé: | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Nottelet, Benjamin, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Porsio,B, Lemaire,L, El Habnouni, Darcos, V, Franconi, F, Garric, X, Coudane, J, Nottelet, B |
| Rok vydání: | 2015 |
| Předmět: |
[CHIM.POLY] Chemical Sciences/Polymers
Materials science Polymers and Plastics Biocompatibility [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Gadolinium chemistry.chemical_element Nanoparticle 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences chemistry.chemical_compound Polymer chemistry Materials Chemistry polyester Chelation Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences [CHIM.POLY]Chemical Sciences/Polymers [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging chemistry Propargyl nanoparticles Amine gas treating 0210 nano-technology Caprolactone MRI |
| Zdroj: | Polymer Polymer, 2015, 56, pp.135-140. ⟨10.1016/j.polymer.2014.11.031⟩ Polymer, Elsevier, 2015, 56, pp.135-140. ⟨10.1016/j.polymer.2014.11.031⟩ |
| ISSN: | 0032-3861 |
| DOI: | 10.1016/j.polymer.2014.11.031 |
| Popis: | International audience; In this work we report on the synthesis of two hydrophobic and degradable gadolinium poly(ε-caprolactone) conjugates and their use for the preparation of MRI-visible nanoparticles intended for diagnosis applications. Advantage has been taken from functional poly(ε-caprolactone)s (PCL) bearing propargyl (PCL-yne) or amine groups (P(CL-co-NH2VL)) to yield conjugates by following two strategies. In a first approach, an azido-chelate of gadolinium (Gd(III)) has been conjugated by CuAAC to PCL-yne to yield a polymeric chelate containing 2.6 wt% of Gd(III). In a second approach, a dianhydride Gd(III)-ligand was reacted with P(CL-co-NH2VL) to yield, after complexation with Gd(III) salts, a polymeric chelate containing 15.4 wt% of Gd(III). The polymers biocompatibility was assessed against L929 fibroblasts. In a second part, advantage was taken from the PCLs conjugates hydrophobicity to easily prepare by nanoprecipitation nanoparticles with diameters ranging from 120 to 170 nm. The nanoparticles MRI-visibility was then evaluated and confirmed under the spin-echo and the clinically relevant gradient-echo MRI sequences. |
| Databáze: | OpenAIRE |
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