Exploiting bone niches: progression of disseminated tumor cells to metastasis
| Autor: | Xiaoxin Hao, Sarah M. Waldvogel, Sergio Aguirre, Aaron M. Muscarella, Xiang Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Niche Bone Neoplasms Breast Neoplasms Bone healing Biology Immune Privilege Models Biological T-Lymphocytes Regulatory Metastasis 03 medical and health sciences 0302 clinical medicine medicine Immune Tolerance Tumor Microenvironment Humans Myeloid Cells Neoplasm Metastasis Stem Cell Niche Review Series Bone metastasis Prostatic Neoplasms General Medicine medicine.disease Hematopoietic Stem Cells Haematopoiesis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer cell Cancer research Disease Progression Neoplastic Stem Cells Female Bone marrow Bone Remodeling Bone Marrow Neoplasms Homeostasis |
| Zdroj: | J Clin Invest |
| ISSN: | 1558-8238 |
| Popis: | Many solid cancers metastasize to the bone and bone marrow (BM). This process may occur even before the diagnosis of primary tumors, as evidenced by the discovery of disseminated tumor cells (DTCs) in patients without occult malignancies. The cellular fates and metastatic progression of DTCs are determined by complicated interactions between cancer cells and BM niches. Not surprisingly, these niches also play important roles in normal biology, including homeostasis and turnover of skeletal and hematopoiesis systems. In this Review, we summarize recent findings on functions of BM niches in bone metastasis (BoMet), particularly during the early stage of colonization. In light of the rich knowledge of hematopoiesis and osteogenesis, we highlight how DTCs may progress into overt BoMet by taking advantage of niche cells and their activities in tissue turnover, especially those related to immunomodulation and bone repair. |
| Databáze: | OpenAIRE |
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