For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder
| Autor: | Gökhan Sarısoy, Haydar Koç, Ayse Erguner Aral, Zeynep Yegin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Bipolar Disorder
Physiology Period (gene) Circadian clock CLOCK Proteins 030209 endocrinology & metabolism Period Circadian Proteins Biology medicine.disease Circadian Rhythm CLOCK 03 medical and health sciences 0302 clinical medicine Physiology (medical) Circadian Clocks medicine Animals Humans Circadian rhythm Bipolar disorder Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Chronobiology international. 38(8) |
| ISSN: | 1525-6073 |
| Popis: | Clock genes play significant roles in the regulation of circadian rhythms, which are thought to be involved in the pathophysiology of neurodegenerative and psychiatric diseases. We aimed to investigate the association of five gene polymorphisms (PER3 VNTR (rs57875989), PER2 rs2304672, CLOCK rs1801260, CLOCK rs10462028, CLOCK rs11932595) with PCR-based methods as potential risk factors in bipolar disorder (BD). We used a multiple testing methodology in BD patients ( |
| Databáze: | OpenAIRE |
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