Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects
| Autor: | Dimitri P. Mikhailidis, John A. Goudevenos, Haralampos J. Milionis, Evangelos C. Rizos, Moses Elisaf, K. Seferiadis |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Population Brain Ischemia Diabetes Complications chemistry.chemical_compound Ischemia Risk Factors Internal medicine medicine Diabetes Mellitus Odds Ratio Humans Obesity Risk factor education Stroke Triglycerides Aged Advanced and Specialized Nursing Metabolic Syndrome education.field_of_study biology Apolipoprotein A-I Cerebral infarction business.industry Cholesterol Cholesterol HDL Fibrinogen medicine.disease Uric Acid Endocrinology Logistic Models chemistry Case-Control Studies Hypertension biology.protein Population study Regression Analysis Female Neurology (clinical) Metabolic syndrome Cardiology and Cardiovascular Medicine business Lipoproteins HDL Lipoprotein(a) |
| Zdroj: | Stroke. 36(7) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose— Metabolic syndrome (MetSyn) represents a constellation of lipid and nonlipid risk factors for cardiovascular disease and is a recognized target for increased behavioral therapy. Objective— The association between acute ischemic/nonembolic stroke and the MetSyn in elderly individuals was assessed in a population-based case-control study in the prefecture of Ioannina, Greece. Study Population— A total of 163 patients aged older than 70 years admitted with first-ever-in-a-lifetime acute ischemic/nonembolic stroke and 166 controls were included. Results— The prevalence of MetSyn (defined according to NCEP/ATP III criteria) was high in stroke patients (46.0% versus 15.7%, P P P =0.012), respectively. The analysis of interaction between MetSyn and its individual components revealed significant associations with abdominal obesity (adjusted OR, 2.74; 95% CI, 1.15 to 6.50; P =0.02), hypertension (OR, 2.03; 95% CI, 0.91 to 4.49; P =0.08), high fasting glucose levels (OR, 2.95; 95% CI, 1.19 to 7.35; P =0.02), high triglyceride (OR, 5.55; 95% CI, 2.71 to 11.37; P P P Conclusions— MetSyn is associated with an increased risk for acute ischemic/nonembolic stroke in elderly subjects with significant contributions from its individual components. In the presence of MetSyn, HDL cholesterol loses its protective role against ischemic stroke. |
| Databáze: | OpenAIRE |
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