Dynamics of thymus organogenesis and colonization in early human development
| Autor: | Eric Vroegindeweij, C. Clare Blackburn, Frances H. Stenhouse, Lucy Morris, Harsh J. Vaidya, Marianne L G Depreter, Alison Farley, Richard A. Anderson, Jan J. Cornelissen, Simon R. Tomlinson, Tom Cupedo |
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| Přispěvatelé: | Hematology |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Colonization
Time Factors Pharyngeal pouch Organogenesis Cellular differentiation Antigens CD34 Mice SCID T-CELL Epithelium Mice 0302 clinical medicine Cell Movement Mice Inbred NOD Pregnancy Hematopoietic Research Articles Epithelial cell differentiation Genetics 0303 health sciences Endoderm Gene Expression Regulation Developmental Cell Differentiation Thymus development DELTA-LIKE 4 Immunohistochemistry Cell biology Carotid Arteries medicine.anatomical_structure HUMAN-FETUS Female Stem cell STEM-CELLS Human EXPRESSION T cell Embryonic Development Thymus Gland Biology 03 medical and health sciences Fetus Immune system medicine Animals Humans Cell Lineage Mesenchyme Progenitor cell Molecular Biology 030304 developmental biology Homeodomain Proteins LINEAGE COMMITMENT EPITHELIAL-CELL DIFFERENTIATION Embryo Mammalian GENE Mice Inbred C57BL PROGENITOR CELLS Leukocyte Common Antigens PAX9 Transcription Factor T-Box Domain Proteins MOUSE THYMUS 030215 immunology Developmental Biology |
| Zdroj: | Farley, A M, Morris, L X, Vroegindeweij, E, Depreter, M L G, Vaidya, H, Stenhouse, F H, Tomlinson, S R, Anderson, R A, Cupedo, T, Cornelissen, J J & Blackburn, C C 2013, ' Dynamics of thymus organogenesis and colonization in early human development ', Development, vol. 140, no. 9, pp. 2015-2026 . https://doi.org/10.1242/dev.087320 Development (Cambridge, England) Development, 140(9), 2015-2026. Company of Biologists Ltd |
| ISSN: | 0950-1991 |
| Popis: | The thymus is the central site of T-cell development and thus is of fundamental importance to the immune system, but little information exists regarding molecular regulation of thymus development in humans. Here we demonstrate, via spatial and temporal expression analyses, that the genetic mechanisms known to regulate mouse thymus organogenesis are conserved in humans. In addition, we provide molecular evidence that the human thymic epithelium derives solely from the third pharyngeal pouch, as in the mouse, in contrast to previous suggestions. Finally, we define the timing of onset of hematopoietic cell colonization and epithelial cell differentiation in the human thymic primordium, showing, unexpectedly, that the first colonizing hematopoietic cells are CD45+CD34int/-. Collectively, our data provide essential information for translation of principles established in the mouse to the human, and are of particular relevance to development of improved strategies for enhancing immune reconstitution in patients. |
| Databáze: | OpenAIRE |
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