Recovery of olfactory function in thirteen-day-old rats after olfactory bulb transplantation but not after olfactory bulb ablation
| Autor: | Karen R. Hendricks, Shelley M. Evers, Jon N. Kott, Mary E. Lee, Lesnick E. Westrum, Mark E. Gregov |
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| Rok vydání: | 1996 |
| Předmět: |
Olfactory system
Male medicine.medical_specialty Central nervous system Physiology Nerve Tissue Proteins Olfaction Biology Lesion Rats Sprague-Dawley Olfactory nerve Pregnancy Internal medicine Olfactory Marker Protein Conditioning Psychological medicine Animals Anesthesia Molecular Biology Neuronal Plasticity Behavior Animal General Neuroscience Age Factors Olfactory Bulb Olfactory bulb Rats Transplantation Smell Endocrinology medicine.anatomical_structure Female Neurology (clinical) medicine.symptom Food Deprivation Biomarkers Developmental Biology Reinnervation |
| Zdroj: | Brain research. 724(1) |
| ISSN: | 0006-8993 |
| Popis: | Previous studies have shown recovery of olfactory ability along with reconnectivity of olfactory nerve (ON) following both olfactory bulb (OB) lesions and OB transplants (TX) when performed in newborn rats. The purpose of the present study is to correlate functional recovery with patterns of anatomical reconnectivity in older, postnatal (PN) 13-day-old rats (a possible critical period for plasticity in the system). Reinnervation of olfactory areas was seen in all OB TX animals regardless of the extent of functional recovery. Eight of nineteen animals with OB TXs demonstrated some degree of behavioral recovery. No reinnervation or behavioral recovery of OB lesion animals was observed. At this age, behavioral recovery is dependent upon reconnectivity within the system and transplantation may be required to facilitate this process. |
| Databáze: | OpenAIRE |
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