Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma
| Autor: | Yoshihiko Hirohashi, Jun-ichi Kobayashi, Kei Tsuchihashi, Takayuki Kanaseki, Terufumi Kubo, Tadashi Hasegawa, Akihiro Miyazaki, Toshihiko Torigoe, Rena Morita, Hiroko Asanuma, Takashi Sasaya, Tomohide Tsukahara, Hiroshi Hirano, Munehide Nakatsugawa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Disease-Free Survival Young Adult Fibrosis Internal medicine Biomarkers Tumor Tumor Microenvironment Overall survival medicine Humans Basal cell Tumor growth Stage (cooking) Aged Aged 80 and over Tumor microenvironment business.industry Cancer General Medicine Middle Aged medicine.disease stomatognathic diseases Carcinoma Squamous Cell Biomarker (medicine) Female Mouth Neoplasms business |
| Zdroj: | Anticancer Research. 40:4319-4326 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14434 |
| Popis: | Background/aim The tumor microenvironment (TME) balances tumor growth and suppression through humoral factors and cell-cell interactions. In oral squamous cell carcinoma (OSCC), TMEs have been associated with prognosis of cancer patients and are evaluated by microscopy; however, these methods of evaluation vary among studies. Materials and methods To evaluate the TME, borderline microenvironment fibrosis (bMF) was evaluated histologically in 236 OSCC cases and used to determine the clinicopathological status. Results bMF was observed in 47% (110 in 236 cases) of OSCC cases and associated with higher T category, N category, stage, histological grade and mode of invasion. bMF-positive was related to overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that bMF-positive was an independent factor for OS in all cases [n=226; HR=1.683 (1.018-2.781); p=0.042], especially in T1+T2 cases [n=186; HR=1.926 (1.079-3.440); p=0.024], and PFS in all cases [n=226; HR=2.254 (1.397-3.637); p=0.001]. Conclusion bMF may act as a novel biomarker for OSCC. |
| Databáze: | OpenAIRE |
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