Metastatic cholangiocarcinoma mimicking tuberculosis in a cow
| Autor: | Susan Sanchez, Daniel R. Rissi, Jessica A Elbert |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Tuberculosis Necrosis 040301 veterinary sciences Cattle Diseases Autopsy Stain Cholangiocarcinoma 0403 veterinary science Animals Medicine Mesentery General Veterinary biology business.industry 0402 animal and dairy science Nodule (medicine) 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040201 dairy & animal science Desmoplasia Bile Ducts Intrahepatic medicine.anatomical_structure Bile Duct Neoplasms Liver Cattle Female Brief Reports medicine.symptom business Mycobacterium |
| Zdroj: | J Vet Diagn Invest |
| ISSN: | 1943-4936 1040-6387 |
| DOI: | 10.1177/10406387211029904 |
| Popis: | Here we describe a metastatic hepatic cholangiocarcinoma (cholangiocellular carcinoma) in a 14-y-old Beefmaster cow that was euthanized because of depression and progressive weight loss. Gross changes included coalescing, white-to-yellow, firm-to-hard nodules with central areas of necrosis and mineralization that effaced much of the hepatic parenchyma, omentum, mesentery, ruminal serosa, and diaphragm. A fresh sample of a hepatic nodule was submitted for a modified acid-fast (MAF) stain during autopsy to rule out tuberculosis. The MAF stain was inconclusive, and the sample was subsequently submitted for a PCR assay for Mycobacterium spp. Histologically, all nodules consisted of a neoplastic proliferation of epithelial cells surrounded by extensive areas of desmoplasia, consistent with a metastatic cholangiocarcinoma. PCR for Mycobacterium spp. was negative. Although the histologic diagnosis in our case was metastatic hepatic cholangiocarcinoma, gross changes were strikingly similar to those described in cases of tuberculosis, highlighting the need to remain vigilant in the identification of zoonotic and suspected foreign animal diseases during autopsy to protect human health. |
| Databáze: | OpenAIRE |
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