Infant serotype specific anti-capsular immunoglobulin G antibody and risk of invasive group B Streptococcal disease
| Autor: | Gaurav Kwatra, Mahtaab Khan, Shabir A. Madhi, Z Dangor, Sanjay G. Lala, Alane Izu |
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| Rok vydání: | 2021 |
| Předmět: |
Serotype
Disease Serogroup medicine.disease_cause Immunoglobulin G Streptococcus agalactiae Serology Pregnancy Conjugate vaccine Streptococcal Infections Humans Medicine General Veterinary General Immunology and Microbiology biology business.industry Streptococcus Public Health Environmental and Occupational Health Infant Transplacental Bayes Theorem Antibodies Bacterial Infectious Diseases Case-Control Studies Immunology biology.protein Molecular Medicine Female Antibody business |
| Zdroj: | Vaccine. 39:6813-6816 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2021.10.022 |
| Popis: | Past studies have mainly investigated the association of serotype-specific capsular IgG in the mother and risk reduction of invasive Group B Streptococcus (GBS) in their young infants. The efficiency of transplacental transfer of IgG could be affected by multiple maternal factors. Hence, investigation of infant serum GBS anti-capsular IgG and risk reduction for invasive GBS disease may be more robust and generalizable. In a matched case-control study, infant serum serotype-specific capsular polysaccharide Ia and III IgG concentrations were analyzed in infants with invasive GBS cases and healthy controls born to women with recto-vaginal colonization by the homotypic serotype. Using Bayesian modeling, an antibody concentration of 2.5 µg/mL and 1 µg/mL predicted a 90% reduced risk of invasive disease for serotype Ia and III, respectively. These data contribute to the possible licensure of a GBS polysaccharide-protein conjugate vaccine, targeted at pregnant women, based on serological correlates of protection against invasive GBS disease. |
| Databáze: | OpenAIRE |
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