Cytokine Status, Thyroid Autoantibodies and Their Dynamic Changes During the Treatment of Graves' Disease
| Autor: | V V Lazanovich, E V Markelova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2008 |
| Předmět: |
biology
business.industry medicine.medical_treatment Graves' disease Thyroid Severe disease General Medicine medicine.disease RC648-665 Anti-thyroid autoantibodies Diseases of the endocrine glands. Clinical endocrinology Resection Cytokine medicine.anatomical_structure Immunology medicine Recurrent disease biology.protein Antibody business |
| Zdroj: | Клиническая и экспериментальная тиреоидология, Vol 4, Iss 3, Pp 28-35 (2008) |
| ISSN: | 2310-3787 1995-5472 |
| Popis: | It has been found during the research that the changes of Th1 and Th2 marker cytokine content in Graves Disease are dynamic and are directly correlated not only with the severity of autoimmune thyrotoxicosis, but also with the method of treatment used and duration of Thiamazole therapy. The beginning of autoimmune thyrotoxicosis shows the largest amounts of both pro-inflammatory (IL-1a, IL-8, IFN-γ) and anti-inflammatory (IL-10) cytokines which are significantly reduced during Thiamazole therapy, with the exception of the cases of severe disease course. Thyroid resection does not result in immunologic remission either, which is confirmed by persisting high serum levels of IL-1a, IL-8, IFN-γ, IL-10 and TSH antibodies in the severe GBD group. Among the unfavorable prognostic factors for recurrent disease are high serum levels of TSH antibodies, IL-1a and IFN-γ during pre-surgery period. |
| Databáze: | OpenAIRE |
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