Clinical Trials of Primary Care Treatments for Major Depression: Issues in Design, Recruitment and Treatment
| Autor: | Michael J. Madonia, Stanley D. Imber, E Rodriguez, Judith R. Lave, Herbert C. Schulberg, Marian R. Block, John L. Coulehan, James M. Perel, C P Scott |
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| Rok vydání: | 1993 |
| Předmět: |
Clinical Trials as Topic
Depressive Disorder medicine.medical_specialty Primary Health Care business.industry Psychological intervention MEDLINE Combined Modality Therapy Mental health Antidepressive Agents law.invention Psychotherapy Clinical trial External validity Psychiatry and Mental health Randomized controlled trial law Humans Medicine Internal validity business Psychiatry Depression (differential diagnoses) |
| Zdroj: | The International Journal of Psychiatry in Medicine. 23:29-42 |
| ISSN: | 1541-3527 0091-2174 |
| DOI: | 10.2190/tptq-m91j-6907-62rw |
| Popis: | The objective of this article is to consider whether randomized clinical trials (RCTs) are able to determine the validity of transferring treatments for major depression from the psychiatric to the primary care sector. This clinical issue is of growing concern in the United States since both governmental and professional bodies are establishing guidelines for the treatment of medical patients with the affective disorder. The article's method involves analysis of how the competing aims of rigorous scientific methodology (internal validity) and generalization of study findings (external validity) are best balanced within the RCT. Experiences in recruiting medical patients with major depression and providing pharmacologic, psychotherapeutic, and usual care interventions compatible with the sociotechnical characteristics of ambulatory medical centers are described to illustrate the complexities of investigating transferability of treatments for major depression with RCT methodology. |
| Databáze: | OpenAIRE |
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