Low skeletal muscle mass is associated with liver fibrosis in individuals with type 2 diabetes and nonalcoholic fatty liver disease
| Autor: | Bajarang Bahadur, Parjeet Kaur, Manish K. Singh, Narendra S. Choudhary, Jasjeet Singh Wasir, Sunil Kumar Mishra, Sakshi Gagneja, Mohammad Shafi Kuchay, Tarannum Bano, Randhir Sud, Harmandeep Kaur Gill, Anu Mathew |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Liver fibrosis Type 2 diabetes Gastroenterology Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Humans Risk factor Muscle Skeletal Hepatology business.industry Confounding nutritional and metabolic diseases medicine.disease Skeletal muscle mass Diabetes Mellitus Type 2 Elasticity Imaging Techniques Female business Transient elastography |
| Zdroj: | Journal of Gastroenterology and Hepatology. 36:3204-3211 |
| ISSN: | 1440-1746 0815-9319 |
| Popis: | BACKGROUND AND AIM Type 2 diabetes (T2D) and low skeletal muscle mass (SMM) are associated with increased risk of nonalcoholic fatty liver disease (NAFLD). However, data regarding the association between low SMM and NAFLD-related liver fibrosis in individuals with T2D are scarce. Therefore, we aimed to investigate the association between low SMM and liver fibrosis in individuals with T2D and NAFLD. METHODS Controlled attenuation parameter (CAP) of ≥ 248 dB/m was taken as cutoff suggesting NAFLD. Clinically relevant liver fibrosis and advanced liver fibrosis were defined as liver stiffness measurement (LSM) by transient elastography (TE) of ≥ 8.0 and ≥ 9.6 kPa, respectively. SMM was measured using dual energy X-ray absorptiometry (DEXA). Low SMM was defined as appendicular SMM index of |
| Databáze: | OpenAIRE |
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