Management of patients with pre-therapeutic advanced liver fibrosis following HCV eradication
| Autor: | Nathalie Ganne-Carrié, Pierre Nahon |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
APRI
AST-to-platelet ratio index PHT portal hypertension medicine.medical_specialty SVR Cirrhosis Hepatocellular carcinoma Liver fibrosis LSM liver stiffness measurement Population DAAs direct-acting antivirals EHC extrahepatic cancer Early detection Review AST aspartate aminotransferase Virological response ALT alanine aminotransferase MACEs major adverse cardiovascular events Internal Medicine medicine Immunology and Allergy SVR sustained virological response FIB-4 fibrosis-4 lcsh:RC799-869 Portal hypertension education Intensive care medicine education.field_of_study AFP alpha-fetoprotein Hepatology business.industry Hazard ratio Liver failure Gastroenterology medicine.disease HR hazard ratio SMR standardised mortality ratio HCV surveillance lcsh:Diseases of the digestive system. Gastroenterology HCC hepatocellular carcinoma business |
| Zdroj: | JHEP Reports, Vol 1, Iss 6, Pp 480-489 (2019) JHEP Reports |
| ISSN: | 2589-5559 |
| Popis: | Summary: Patients with HCV-related bridging fibrosis or cirrhosis remain at risk of developing life-threatening complications even after achieving a sustained virological response. Although it is reduced, the risk of liver-related events in these patients justifies their inclusion in surveillance programmes dedicated to the early detection of hepatocellular carcinoma and the screening for portal hypertension. Biochemical parameters or non-invasive tests might indicate the potential progression of liver injury despite viral clearance. Specific attention must be focused on the management of comorbidities, while dedicated educational programmes must be encouraged to increase compliance and commitment to surveillance. Better knowledge of the long-term evolution of these patients, who now live longer, is essential to improve risk stratification and refine screening strategies in this growing population. Keywords: HCV, Hepatocellular carcinoma, Liver failure, Portal hypertension, surveillance, SVR |
| Databáze: | OpenAIRE |
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