Factors predicting survival in thick melanoma: Do all thick melanomas have the same prognosis?
| Autor: | Steven Morrison, John T. Vetto, Jonathan S. Zager, Gang Han, Richard L. White, Barbara A. Pockaj, Nicola Mozzillo, Schlomo Schneebaum, Mohammed Kashani-Sabet, Dale Han, Vernon K. Sondak, Stanley P. L. Leong |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Lymphovascular invasion Dermatologic Surgical Procedures Sentinel lymph node Kaplan-Meier Estimate 030230 surgery Thick melanoma Disease-Free Survival Metastasis 03 medical and health sciences 0302 clinical medicine Biopsy medicine Overall survival Humans Neoplasm Invasiveness Melanoma Aged Lymphatic Vessels Retrospective Studies Skin medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Middle Aged Prognosis medicine.disease Tumor Burden Lymphatic Metastasis 030220 oncology & carcinogenesis Blood Vessels Female Surgery Radiology Neoplasm Recurrence Local Sentinel Lymph Node business Follow-Up Studies |
| Zdroj: | Surgery. 168:518-526 |
| ISSN: | 0039-6060 |
| DOI: | 10.1016/j.surg.2020.04.048 |
| Popis: | Background It is unknown whether all thick melanomas share the same prognostic features. We present a large, multi-institutional study on thick melanoma, evaluating for factors prognostic of survival. Methods We queried the database of the Sentinel Lymph Node Working Group for patients with thick melanoma (>4 mm) who had a sentinel lymph node biopsy from 1993 to 2018. Clinicopathologic characteristics were correlated with overall survival. Results There were 1,235 patients with a median follow-up of 28 months. Median thickness was 5.9 mm, with 713, 356, and 166 cases having a thickness of >4 to 6, >6 to 10, and >10 mm, respectively. Ulceration was seen in 51.2% of cases, while sentinel lymph node metastases were seen in 439 of 1,235 (35.5%) cases. For melanomas >4 to 6 mm, age, thickness, ulceration, lymphovascular invasion, and sentinel lymph node metastasis were correlated with overall survival (all P 6 to 10 mm, only sex and sentinel lymph node metastasis were prognostic of overall survival (both P 10 mm, only sentinel lymph node metastasis predicted overall survival on multivariable analyses (P Conclusion Prognostic markers of overall survival for thick melanoma include thickness, ulceration, and sentinel lymph node metastasis, but also include other unique factors such as lymphovascular invasion. Moreover, certain prognostic markers for survival are associated with different subgroups of thick melanoma, which vary based on thickness group. |
| Databáze: | OpenAIRE |
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