Potential therapeutic system for Alzheimer’s disease: removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients
| Autor: | Tatsuro Mutoh, Hiroshi Ogawa, Yukio Yuzawa, Satoshi Sugiyama, Hiroko Kusimoto, Kazutaka Murakami, Yoshiyuki Hiki, Hideo Hori, Yasunobu Shimano, Nobuo Suzuki, Shinji Ito, Nobuya Kitaguchi, Atsushi Ohashi, Sigeru Nakai, Kazunori Kawaguchi, Masao Kato |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Neurology medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Disease Neuropsychological Tests chemistry.chemical_compound Cerebrospinal fluid Alzheimer Disease Renal Dialysis Internal medicine medicine Humans Senile plaques Pathological Biological Psychiatry Aged Creatinine Amyloid beta-Peptides business.industry Peripheral Psychiatry and Mental health chemistry Cardiology Kidney Failure Chronic Female Neurology (clinical) Hemodialysis Cognition Disorders business |
| Zdroj: | Journal of Neural Transmission. 119:1533-1544 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | The pathological changes of Alzheimer’s disease include the deposition of amyloid β protein (Aβ) as senile plaques in the brain. We hypothesized that the rapid removal of Aβs from the blood may act as a peripheral Aβ drainage sink from the brain. In this study, the plasma Aβ concentrations and the cognitive functions were investigated for in 57 patients on hemodailysis (69.4 ± 3.8 years), 26 renal-failure patients without hemodialysis (66.6 ± 14.7 years), and 17 age-matched healthy controls (66.6 ± 4.1 years). The concentrations of plasma Aβs increased along with the decline of renal functions. Moreover, the renal-failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. The plasma concentrations of Aβ1-42 correlated with serum creatinine (P |
| Databáze: | OpenAIRE |
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