Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine
| Autor: | Heather A. Emmons, Sarah A. Hutcherson, Steve C. Fordahl, Nari S. Beatty, Conner W. Wallace, Madison C. Loudermilt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Dopamine
Stimulation Synaptic Transmission Nucleus Accumbens Mice 0302 clinical medicine elevated plus-maze Weight loss Opioid receptor Medicine TX341-641 Diet Fat-Restricted 0303 health sciences Nutrition and Dietetics digestive oral and skin physiology anxiety-like behavior dopamine neurotransmission medicine.symptom medicine.drug medicine.medical_specialty Elevated plus maze κ-opioid receptors diet-induced obesity medicine.drug_class Fast-scan cyclic voltammetry Nucleus accumbens Diet High-Fat Article 03 medical and health sciences fast-scan cyclic voltammetry Internal medicine Animals Obesity nucleus accumbens core 030304 developmental biology high-fat diet replacement business.industry Nutrition. Foods and food supply Receptors Opioid kappa medicine.disease Dietary Fats Mice Inbred C57BL Disease Models Animal Endocrinology novelty-induced hypophagia business 030217 neurology & neurosurgery Food Science |
| Zdroj: | Nutrients Volume 13 Issue 7 Nutrients, Vol 13, Iss 2341, p 2341 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13072341 |
| Popis: | Diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (NAc), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. Activation of κ-opioid receptors (KORs) reduces synaptic dopamine, but contribution of KORs to lower dopamine tone after dietary changes is unknown. Therefore, the purpose of this study was to determine the function of KORs in C57BL/6 mice that consumed a 60% high-fat diet (HFD) for six weeks followed by replacement of HFD with a control 10% fat diet for one day or one week. HFD replacement induced voluntary caloric restriction and weight loss. However, fast-scan cyclic voltammetry revealed no differences in baseline dopamine parameters, whereas sex effects were revealed during KOR stimulation. NAc core dopamine release was reduced by KOR agonism after one day of HFD replacement in females but after one week of HFD replacement in males. Further, elevated plus-maze testing revealed no diet effects during HFD replacement on overt anxiety. These results suggest that KORs reduce NAc dopamine tone and increase food-related anxiety during dietary weight loss interventions that could subsequently promote palatable food cravings and inhibit weight loss. |
| Databáze: | OpenAIRE |
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